Toward understanding of extracellular superoxide dismutase regulation in atherosclerosis: a novel role of uric acid?
نویسندگان
چکیده
Superoxide dismutases (SODs) represent the major antioxidant defense system against superoxide anions (O2 ). Three isoforms of superoxide dismutase have been identified in mammals: copper-zinc SOD (Cu, ZnSOD), manganese SOD (Mn-SOD), and extracellular SOD (ecSOD). Cu, Znand Mn-SOD are localized intracellularly, whereas the last discovered SOD isoform, ecSOD,1 is secreted and bound to heparan sulfate on the cellular surface.
منابع مشابه
Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity.
OBJECTIVE The cytosolic form of Cu/Zn-containing superoxide dismutase (SOD1) has peroxidase activity, with H2O2 used as a substrate to oxidize other molecules. We examined peroxidase properties of the extracellular form of SOD (SOD3), a major isoform of SOD in the vessel wall, by using recombinant SOD3 and an in vivo model of atherosclerosis. METHODS AND RESULTS In the presence of HCO3-, SOD3...
متن کاملEffect of endoplasmic reticulum (ER) stress inducer thapsigargin on the expression of extracellular-superoxide dismutase in mouse 3T3-L1 adipocytes
Endoplasmic reticulum stress is related to metabolic disorders, including atherosclerosis and type 2 diabetes. It is known that inflammatory adipocytokines and oxidative stress are increased, while anti-inflammatory adipocytokines such as adiponectin are decreased in adipocytes during above conditions. Extracellular-superoxide dismutase is an anti-inflammatory enzyme that protects cells from ox...
متن کاملRelationship of Uric Acid with Superoxide Dismutase (Sod) in Induced Hyperuricemic Rat Model
Increase uric acid levels have been found in oxidative stress. Urate radicals do not react with oxygen to form another peroxy radical, thus increasing the efficacy of uric acid as an antioxidant. Therefore, this study is designed to measure the level of uric acids and find out the relationship of uric acid with superoxide dismutase in induced hyperuricemic model. Forty male albino rats with an ...
متن کاملInfluence of dyslipidemia and smoking on redox markers in humans--a critical study.
UNLABELLED Experimental research indicates that oxidative processes play a role in susceptibility to a large number of diseases. A better understanding of the parameters affecting redox balance could delay and even prevent such processes. OBJECTIVE The present study aims to investigate blood parameters associated with antioxidant systems in a Portuguese population for the first time, taking i...
متن کاملبررسی مقایسه‌ای آنتی‌اکسیدان‌های بزاق در دیابت بارداری و زنان باردار سالم
Background and objective: Few studies have shown the role of oxidative stress in gestational diabetes mellitus. Increased oxidative stress and antioxidant defense dysfunction could be one of the etiologic factors in gestational diabetes mellitus. The aim of this study was to evaluate levels of salivary antioxidants in pregnant women with gestational diabetes mellitus and their comparison with n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 22 9 شماره
صفحات -
تاریخ انتشار 2002